强骨胶囊联合甲氨蝶呤对类风湿关节炎骨破坏防治疗效的评估

Evaluation of Effect of Qianggu Capsule Combined with Methotrexate on Bone Destruction in Rheumatoid Arthritis

目的评估强骨胶囊与甲氨蝶呤(MTX)联合应用治疗类风湿关节炎的临床效果,及对类风湿关节炎骨破坏的防治疗效。方法选择2010年1月～2011年6月在我院确诊为类风湿关节炎的早期患者52例,分为治疗组(n=25)和对照组(n=27)。治疗组采用强骨胶囊联合甲氨蝶呤和双氯芬酸钠治疗,共6个月;对照组采用甲氨蝶呤和双氯芬酸钠治疗,共6个月。比较分析治疗前后患者的主要症状、临床体征及健康评价调查表评分及血沉(ESR)、C反应蛋白(CRP)、骨密度的变化情况,评估强骨胶囊联合甲氨蝶呤对类风湿关节炎的临床效果,及对类风湿关节炎骨破坏的防治疗效。结果治疗组治疗后主要症状体征较治疗前明显改善,中医症候积分、HAQ评分平均值明显低于对照组,差异有统计学意义(P<0.05);治疗组用药后骨密度比治疗前升高,有统计学意义(P<0.05),对照组无升高(P>0.05)。结论强骨胶囊联合甲氨蝶呤能有效缓解类风湿关节炎患者的临床症状,提高患者的骨密度,延缓甚至减轻骨破坏,从而改善患者的生活质量。

Objective To observe the clinical efficacy of Qianggu Capsule combined with methotrexate （MTX） on rheumatoid arthritis and appraise it＇ s preventive effect on bone destruction. Methods A total of 52 patients, who were diagnosed with rheumatoid arthritis（early stage） in our hospital from Jan. 2010 to Jun. 2011, were enrolled for this study. Patients were divided into treatment group （n=25） and control group （n=27）. Patients in the control group received MTX and Diclofenac Sodium Dual Release Enteric-coated Capsule, while patients in the treatment group were administered with Qianggu Capsule combined with MTX and Diclofenac Sodium Dual Release Enteric-coated Capsule. The course of treatment lasted for 6 months. The health assessment questionnaire （HAQ） score, Chinese medical pattern grade, ESR, CRP, BMD and so on were retrospectively analyzed. Results There was significantly difference between control group and treatment group on Ritchit index, HAQ and Chinese medical pattern grade after treatment（P〈0.05）. The treatment group was better than the control group after treatment（P〈0.05）. After 6 months of treatment, the treatment group was developed obviously on BMD（P〈0.05）. Conclusion Qianggu Capsule combined with methotrexate can alleviate the clinical symptoms of rheumatoid arthritis, increase bone mineral density and improve the quality of life of patients.