炎琥宁联合阿奇霉素治疗毛细支气管炎50例疗效观察

50 cases of effect observation of dehydroan drographolide succinate and azithromycin in treating bronchiolitis

目的:探讨炎琥宁联合阿奇霉素治疗婴幼儿毛细支气管炎的临床疗效。方法:100例毛细支气管炎患儿随机分为治疗组50例和对照组50例,2组患儿均采用抗感染、止咳、吸痰、雾化等常规综合治疗,治疗组在综合治疗的基础上加用炎琥宁联合阿奇霉素治疗,对治疗后症状、体征改善时间进行比较,随访半年,记录患儿出院后反复喘息发作的次数。结果:治疗组总有效率96.0%,对照组总有效率84.0%,2组总有效率比较,差异有统计意义(P<0.05)。治疗组喘憋、咳嗽、哮鸣音消失时间和住院天数较对照组短,差异有高度统计意义(P<0.01)。随访半年,治疗组喘息发生率为4%(4/50),对照组为26%(13/50),差异有统计意义(P<0.05)。2组均未见明显不良反应。结论:炎琥宁联合阿奇霉素治疗毛细支气管炎疗效显著、安全,可减少患儿日后喘息发作。

Objective： To investigate the clinical effect of dehydroan drographolide succinate and azithromycin on bronchiolitis. Methods： 100 cases of bronchiolitis were randomized into the treatment group （ 50 cases） and the control group （ 50 cases ）. Both groups adopted anti-infection, cough-stopping, sputum suction, atomization inhala- tion and other conventional treatment. Treatment group used dehydroan drographolide suecinate and azithromycin, the clinical effects were evaluated in both groups after the treatment. After 6 months follow up, and study the recur- rence rate of bronchiolitis. Results： The total effective rate was 96.0% in treatment group, 84.0% in control group. The difference has statistical meaning（P〈0.05）. The extinction time in cough, release of asthma, wheeze- ing sound and average time of hospitalization were shorter than that of the control group with significant differences （ P〈0.01 ）. And the recurrence rate were 4% and 26%. No obvious adverse reaction was observed. Conclusion： Dehydroan drographolide succinate and azithromycin in the treatment of bronchiolitis is significantly effective and safe, can decrease pediatric recurrence wheezing.