期刊文献+

宫颈癌相关基因DNA甲基化研究进展 被引量:6

下载PDF
导出
摘要 近年研究发现宫颈癌的发生发展可能与表观遗传的改变有很大联系。DNA甲基化是表观遗传学重要的分子机制之一。近年来,国内外对宫颈癌DNA甲基化的研究越来越多,发现多种基因在宫颈癌的发生发展中发生了甲基化修饰,且这种表观遗传学改变与宫颈病变程度有一定相关性。许多研究提出宫颈癌有关的DNA甲基化检测可能用于临床宫颈癌和癌前病变的诊断或预测。
出处 《中外医学研究》 2013年第5期150-154,共5页 CHINESE AND FOREIGN MEDICAL RESEARCH
  • 相关文献

参考文献51

  • 1Parkin D M,Bray F,Ferlay J. Global cancer statistics,2002[J].CA Cancer J C lin,2005,(01):74-78.
  • 2Ahmedin J,Freddie B,Melissa M. Global cancer statistics,2011[J].{H}CA-A Cancer Journal for Clinicians,2011,(02):69-90.
  • 3Laird P W. Principles and challenges of genome-wide DNA methylation analysis[J].{H}Nature Reviews Genetics,2010,(03):191-203.
  • 4Bhutani N,Brady J J,Damian M. Reprogramming towards pluripotency requires AID-dependent DNA demethylation[J].{H}NATURE,2010,(7284):1042-1047.
  • 5Tomita H,Hiratr A,Yamada Y. Suppressive effect of global DNA hypomethylation on gastric carcinogenesis[J].{H}CARCINOGENESIS,2010,(09):1627-1633.
  • 6Wolff E M,Byun H M,Han H F. Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer[J].{H}PLoS Genetics,2010,(04):917-1000.
  • 7Sharma S,Kelly T K,Jones P A. Epigenetics in cancer[J].{H}CARCINOGENESIS,2010,(01):27-36.
  • 8Widschwendter A,Gattringer C,Lvarsson L. Analysis of aberrant DNA methylation and human papillomavirus DNA in cervicovaginal specimens to detect invasive cervical cancer and its precursors[J].{H}Clinical Cancer Research,2004,(10):3396-3400.
  • 9Feng Q,Hawes S E,Stem J E. Promoter hypermethylation of tumor suppressor genes in urine from patients with cervical neoplasia[J].{H}Cancer Epidemiology Biomarkers & Prevention,2007,(15):1178-1184.
  • 10Widschwendter A,Ivarsson L,Blassnig A. CDH1 and CDH13 methylation in serum is an independent prognostic marker in cervical cancer patients[J].{H}International Journal of Cancer,2004,(02):163-166.

同被引文献89

  • 1姜淑清,王涛,土送爱,周俊兰,买热木沙汗,徐雪,海日尼沙汗,茹仙姑丽,沙来买提,艾木热汗,邓小虹.新疆策勒县宫颈癌的流行病学调查研究[J].中国实用妇科与产科杂志,2006,22(5):379-381. 被引量:43
  • 2古扎丽努尔.阿不力孜,程静新,米克热木,古兰丹,李华,米合日尼沙,米日古丽,米日古丽.艾乃土,路玲.新疆维吾尔族妇女宫颈癌的HPV谱研究[J].肿瘤,2007,27(5):379-382. 被引量:48
  • 3Kang YH, Galal WC, Farina A, et al. Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in roiling circle DNA synthesis [J].Proc Natl Acad Sci USA ,2012,109(16) :6042-6047.
  • 4Rusiniak ME, Kunnev D, Freeland A, et al. Mcm2 deficiency re- suits in short deletions allowing high resolution identification of genes contributing to lymphoblastic lymphoma [J].Oncogene,2012,31 (36): 4034-4044.
  • 5Boos D, Frigola J, Diffley JF. Activation of the replicative DNA he- licase: breaking up is hard to do [J].Curr Opin Cell Biol,2012,24 (3) : 423-430.
  • 6Forsburg SL. The MCM helicase:linking checkpoints to the replica- tion fork[J]. Biochem Soc Trans, 2008,36 (Ptl) : 114-119.
  • 7Yang C, Wen Y, Li H, et al. Overexpression of minichromosome maintenance 2 predicts poor prognosis in patients with gastric cancer[J]. Oncol Rep, 2012,27 ( 1 ) : 135-142.
  • 8Wojnar A, Pula B, Piotrowska A, et al. Correlation of intensity of MT-I/II expression with Ki-67 and MCM-2 proteins in invasive ductal breast carcinoma[J]. Anticancer Res, 2011,31 (9) : 3027-3033.
  • 9Saeb-Parsy K, Wilson A, Scarpini C, et al. Diagnosis of bladder cancer by immunocytochemical detection of minichromosome mainte- nance protein-2 in cells retrieved from urine [J]. Br J Cancer, 2012,107(8) : 1384-1391.
  • 10Ishimi Y, Okayasu I, Kato C, etal. Enhanced expression of Mcm proteins in cancer cells derived from uterine cervix [J]. Eur J Biochem, 2003,270(6) .. 1089-1101.

引证文献6

二级引证文献23

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部