我国解脲支原体感染与男性不育关系的Meta分析

Meta analysis of the relationship between ureaplasma urealyticum infection and male infertility in China

目的了解解脲支原体（ureaplasmaurealyticum，UU）感染与男性不育的关系。方法采用Meta方法，对我国男性不育患者uu感染率及其与血清抗精子抗体、精液参数的关系进行分析。结果不育者与正常组UU感染阳性率OR=4．08（95％CI为3．37～4．93），UU感染者与UU阴性者AsAb发生率OR=2．68（95％CI为2．18～3．30），UU感染者与UU阴性者精子密度OR=．15．74（95％CI为．7．6-15．43）。结论不育患者感染uU阳性率明显高于正常对照组，UU感染可以引起血清抗精子抗体产生增加，精子密度下降，精液质量下降，是男性不育的重要危险因素。

Objective To investigate the relation ofUreaplasma urealyticum infection and male infertility. Methods The changes of serum anti-sperm antibodies and semen parameters in male infertility with ureaplasma urealyticum infections were analyzed using Meta analysis methods. Results The combined UU infection rate ORs of male sterility and the normal control were OR =4.08（95%CI：3.37-4.93）, the combined AsAb positive rate ORs of Uu and normal control were OR=2.68（95%CI：2.18-3.30）,the combined sperm concentration ORs of Uu and normal control were OR =- 15.74（95%CI：-7.6--15.43）. Conclusion The positive rate of male infertility with UU infection in the infertility group were significiantly higher than that of the normal group. UU infections might increase serum antibodies production, decrease the sperm concentration, which was an important risk factor formale infertility.