食管癌分子靶向治疗临床研究的新进展

Targeted therapies for esophageal cancer

食管癌是最常见的恶性肿瘤之一,早期诊断率较低,大部分患者在就诊时已属晚期.虽然近几年外科手术技术的提高、化疗新药的出现以及术前新辅助放化疗均可提高晚期食管癌的生存率,但晚期食管癌的预后仍差,仍需要新的治疗手段来提高晚期食管癌的疗效.随着肿瘤分子生物学的研究进展,分子靶向治疗已经在食管癌的治疗中初显成效.目前,食管癌的分子靶向治疗已经成为国内外的研究热点之一.

Esophageal cancer is a highly frequent malignancy, being the fourth leading cause of cancer-related deaths in China. Most patients are initially diagnosed with advanced disease. Despite recent advances in surgical techniques and adjuvant/neoadjuvant radiotherapy and chemotherapy, the prognosis of esophageal cancer is still poor. An emerging understanding of molecular pathways that characterizes cell growth, cell cycle, apoptosis, angiogenesis, and invasion has provided novel targets for cancer therapy. This review focuses on novel targeted treatments for esophageal cancer.