尾加压素Ⅱ在肝硬化门脉高压及侧支循环中的作用

Role of urotensin-Ⅱ in the pathogenesis of liver cirrhosis and portal hypertension and collateral circulation

尾加压素(urotensin-Ⅱ,UⅡ)是一种生长抑素样环肽,具有强有效的血管活性作用,并能促进血管重建和增生.研究显示,UⅡ与肝硬化门脉高压的形成有关,通过多种途径影响肝内血管阻力和外周循环血量,引起门脉压力升高,参与食管胃静脉曲张等侧支循环形成.应用UⅡ受体拮抗剂能降低肝硬化大鼠的门脉压力,但有待于在临床上做进一步研究.

Urotensin-Ⅱ （U-Ⅱ） is a somatostatin-like cyclic peptide which has a potent vasoactive effect and can promote vascular reconstruction and hyperplasia. Research shows that UⅡ plays an important role in the development of liver cirrhosis and portal hypertension. UⅡ influences intrahepatic resistance and splanchnic hemodynamics through a variety of pathways, causing portal hypertension and participating in the formation of esophageal and gastric varices. UⅡ receptor antagonists can reduce portal pressure in cirrhotic rats, but this finding need to be confirmed clinically.