抑瘤素M与肝脏再生、肝脏疾病关系的研究进展

Advances in understanding the relationship between oncostatin M and liver regeneration and liver diseases

抑瘤素M(oncostatinM,OSM)是一种多功能细胞因子,属白细胞介素6(interleukin-6,IL-6)家族成员,在这些所有成员中,OSM与白血病抑制因子(leukemia inhibitory factor,LIF)在结构和功能上最为接近.OSM有Ⅰ型和Ⅱ型两种类型受体(OSM receptor,OSMR),OSM通过与受体结合启动JAK-STAT及MAPK信号通路从而介导其生物学作用.OSM除具有抑制某些肿瘤细胞生长功效外,还可作用于其他多种细胞,参与众多的生理病理过程,在多种疾病中发挥重要作用,包括调节炎症反应、刺激造血、调节胆固醇代谢、保护神经系统等.新近研究表明,在肝脏疾病中,OSM参与肝脏再生,并与病毒性肝炎、非酒精性脂肪性肝病、肝纤维化、肝细胞癌等的发生发展和转归密切相关.此文就OSM与肝脏疾病关系的研究进展进行综述.

Oncostatin M（OSM） is a pleiotropic cytokine belonging to the interleukin（IL）-6 family of cytokines.It is closely related structurally and functionally to leukemia inhibitory factor（LIF）.There are two types of functional OSM receptors（OSMR）：I and II.The binding of OSM to its receptors activates the JAK-STAT and MAPK signal pathways.OSM not only inhibits the proliferation of tumor cells but also participates in several physiological and pathological processes in a variety of cell types and plays key roles in the pathogenesis of multiple diseases,including regulation of inflammatory responses,stimulation of hematopoiesis,regulation of cholesterol metabolism,and induction of neurotrophic peptides.Recent studies suggest that OSM participates in liver regeneration and is closely related to the occurrence and progression of viral hepatitis,non-alcoholic fatty liver disease,liver fibrosis,and liver cancer.This article reviews recent advances in understanding the relationship between OSM and liver generation and liver diseases.