急性胰腺炎硬膜外治疗的研究进展

Recent advances in the use of epidural anesthesia for acute pancreatitis

急性胰腺炎(acute pancreatitis,AP)是一种由多因子引起的常见病、急性病,且易并发多种全身症状,继而引发多器官功能衰竭,死亡率高.由于其发病机制尚未阐明,目前临床上尚缺乏行之有效的治疗方法.自从1969年Browne第一次描述硬膜外阻滞对AP的积极作用以来,许多学者对其进行了探讨.近年来人们发现硬膜外阻滞能通过镇痛、抑制炎性因子释放、促进腺泡细胞凋亡及改善胰腺微循环等机制抑制AP的进展,改善其转归.本文对其治疗作用的研究进展作一综述.

Acute pancreatitis（AP） is a common acute disease caused by a number of factors.It can cause a variety of systemic symptoms and multiple organ failure（MOF）,having a high mortality rate.Currently,there is still a lack of effective treatment for AP because its pathogenesis has not been elucidated.The positive role of epidural anesthesia for AP was firs described by Browne in 1969.In recent years,it has been found that epidural anesthesia can prevent the progression of AP by inducing analgesia,inhibiting the release of inflammatory factors,promoting acinar cell apoptosis,and improving pancreatic microcirculation.In this paper,we will review recent progress in the use of epidural anesthesia for AP.