结直肠癌肝转移治疗的研究进展

Advances in treatment of liver metastases of colorectal cancer

结直肠癌肝转移的发生率和死亡率很高,是影响结直肠癌预后的重要因素.因此,找到合理的治疗方案显得尤为重要.目前手术切除仍被认为是唯一可能有效的治愈手段,但能手术根治的患者仅占少数.因此,随着医疗技术的发展,肝转移癌治疗经验的积累,多学科综合治疗理念逐渐被广泛应用,是确保结直肠癌肝转移患者获得最佳治疗策略的根本,亦是今后结直肠癌肝转移治疗的发展方向.多学科综合治疗方案包括手术切除、新辅助化疗、肝动脉化疗栓塞、放射疗法、射频消融术、冷冻疗法、无水乙醇注射术及中医药治疗等,一种或多种方法联合应用可明显提高患者的生存率并改善生活质量,本文对结直肠癌肝转移的综合治疗进展作一综述.

Liver metastasis of colorectal cancer has a high incidence and mortality and is the main factor affecting prognosis,which necessitates the development of more reasonable therapeutic strategy for this condition.Nowadays,surgical resection is the only probable curative method;however,surgical intervention is indicated in only a few patients.The development of medical technology and accumulation of clinical experience have led to the wide use of multimodal treatment for liver metastases of colorectal cancer.Multimodal treatment includes surgical resection,neoadjuvant chemotherapy,transcatheter hepatic arterial chemoembolization,radiation therapy,radiofrequency ablation,cryotherapy,percutaneous ethanol injection,and Chinese medicine treatment.The combined application of the above treatments can improve the survival rate and the quality of life of patients.This article summarizes the advances in comprehensive treatment for colorectal liver metastases.