血清肝纤维化HA、Ⅳ-C、PCⅢ和LN联合检测在布加综合征导致的肝纤维化诊断中的价值

Detection of serum levels of HA,Ⅳ-C,PCⅢ and LN in patients with Budd-Chiari syndrome

目的:探讨血清透明质酸(hyaluronic acid,HA)、Ⅳ型胶原(type Ⅳ collagen,Ⅳ-C)、Ⅲ型前胶原肽(type Ⅲ procollagen,PCⅢ)、层黏连蛋白(laminin,LN)检测在布加综合征(budd-chiari syndrome,BCS)导致肝纤维化诊断的价值.方法:应用化学发光法分别检测我院介入科2004-03/2012-06收治的61例BCS患者(研究组)及60例健康者(对照组)血清HA、Ⅳ-C、PCⅢ、LN含量,并进行统计学分析.结果:BCS患者血清HA、Ⅳ-C、PCⅢ、LN含量均高于对照组,差异具有统计学意义,分别为t=6.879,P<0.05;t=7.071,P<0.05;t=5.753,P<0.05;t=6.330,P<0.05.研究组进行组间比较,血清HA、Ⅳ-C、PCⅢ、LN含量差异无统计学意义(P>0.05).结论:血清HA、Ⅳ-C、PCⅢ、LN作为检测肝纤维化灵敏指标,联合检测对BCS导致肝纤维化的诊断和临床治疗具有重要意义.

AIM：To detect serum levels of hyaluronic acid（HA）,type Ⅳ collagen（Ⅳ-C）,type Ⅲ procollagen（PCⅢ） and laminin（LN） in patients with Budd-Chiari syndrome（BCS）.METHODS：Serum levels of HA,Ⅳ-C,PCⅢand LN in 61 BCS patients（study group） and 60 healthy persons（control group） were measured by chemiluminescence and compared between the two groups.In addition,the patients were divided into the following subgroups for comparison of the above parameters：inferior vena cava type,hepatic vein type,and mixed type.RESULTS：Serum levels of HA,Ⅳ-C,PCⅢ and LN were significantly higher in patients with BCS than in controls（t=6.879,7.071,5.753,6.330;all P〈0.05）.However,there were no significant differences in serum levels of HA,Ⅳ-C,PCⅢand LN between patients with different subtypes of BCS（all P〈0.05）.CONCLUSION：Serum levels of HA,Ⅳ-C,PCⅢ and LN were significantly higher in patients with BCS,and combined detection of these parameters may be helpful for the diagnosis of liver fibrosis caused by BCS.