CD40在溃疡性结肠炎组织中的表达及意义

Significance of expression of CD40 in ulcerative colitis

目的:研究CD40分子在溃疡性结肠炎组织中的表达及其与溃疡性结肠炎严重度之间的相关性.方法:收集2008-01/2011-10本院收治的溃疡性结肠炎患者56例,同时收集同期健康体检者10例.应用免疫组织化学技术检测溃疡性结肠炎组织和正常结肠组织中CD40分子的表达.结果:CD40分子在溃疡性结肠炎组织中的阳性表达率明显高于对照组(62.50%vs20.00%,χ2=6.2217,P<0.05).与轻度溃疡性结肠炎相比,CD40阳性表达率在中度溃疡性结肠炎中明显升高(90.00%vs39.28%,P<0.05).结论:CD40在溃疡性结肠炎组织中存在异常表达.

AIM：To investigate the expression of CD40 in ulcerative colitis.METHODS：The expression of CD40 protein was detected by immunohistochemistry in 56 cases of human ulcerative colitis and 10 case of normal colon tissue.RESULTS：The positive rate of CD40 expression in active ulcerative colitis was significantly higher than that in normal colon tissue（62.50% vs 20.00%,χ2 = 6.2217,P〈0.05）.The positive rate of CD40 expression was significantly higher in moderately than in mildly active ulcerative colitis（P〈0.05）.CONCLUSION：CD40 is abnormally expressed in colon tissue of patients with ulcerative colitis.