慢性乙型肝炎抗病毒联合治疗:证据、争议、研究方向

Current perspectives on the efficacy and mechanisms of combination therapy for chronic hepatitis B virus

抗病毒治疗是控制慢性乙型肝炎、防止肝硬化、肝癌发生的主要手段。而目前现有的抗病毒药物的疗效不能令人满意,为进一步优化治疗的应答,不同作用机制、或耐药位点不同的抗病毒药物进行联合治疗是一个值得探索的重要选择。相关研究虽已取得一些进展,积累了一定的证据,但仍然存在不少问题和争议,这有待于对其发病及治疗应答不佳机制的深入了解。

The antiviral therapy is a main method to control chronic hepatitis B and prevent cirrhosis and hepatocarcinoma.However,the efficacy of current antiviral drugs are unsatisfactory.In order to optimize the antiviral strategy,it is worthy to investigate an important choice to combine antiviral drugs of different antiviral mechanism or different antiviral drug resistances.Although some relative studies and evidences have been taken,there are still many problems and arguments about combination therapy,which needs deep understanding of the pathogenesis and mechanism of poor antiviral response.