SUMO化修饰与血液系统疾病

Sumoylation and Its Role in Hematological Disease

小泛素相关修饰物(SUMO)修饰为继泛素化修饰后又一种主要的蛋白翻译后修饰,参与调控多种细胞生命活动,如蛋白质间相互作用、胞内定位、DNA修复、转录因子的活化,以及细胞周期和转录的调控等,并与多种疾病的发病密切相关。近年来的研究表明,SUMO化修饰也参与了多种血液系统疾病的发病。本文综述了SUMO化修饰对血液系统疾病发病及治疗的影响。

Small ubiquitin-related modifier（SUMO） can be covalently attached to target proteins and thereby plays a crucial role in regulating the normal functions of cells, such as protein-protein interaction, subcellu]ar localization, DNA repair, cell cycle and transcription factor regulation. Several lines have imp^cated that sumoylation is important in disease occurrence and development. This brief review will focus on some recent findings about the roles of sumoylation in the etiology and treatment of hematological malignancies.