PI3K／AKT／mTOR信号通路在造血干细胞中作用的研究进展

Recent Studies on PI3K/AKT/mTOR Signaling Pathway in Hematopoietic Stem Cells

PI3K/AKT/mTOR信号通路调节细胞生长、增殖和存活等生命过程,在多种细胞生命过程中起着关键的作用,在造血干细胞中同样也扮演着重要的角色。过度激活PI3K/AKT/mTOR信号通路会造成造血干细胞的耗竭,而抑制PI3K/AKT/mTOR信号通路,则B细胞的分化会受到显著的抑制。本文系统介绍PI3K/AKT/mTOR信号通路中关键节点的蛋白,包括PI3K,AKT,mTOR,FoxO和GSK-3等在造血干细胞中作用的最新研究进展。

PI3K/AKT/mTOR signaling pathway plays an essential role in the growth, proliferation and survival of various type of cells and also hematopoietic stem cells （HSC）. Aberrant activation of PI3K/AKT/mTOR signaling pathway leads to exhaustion of HSC, while the inhibition of PI3K/AKT/mTOR signaling pathway results in blocking of B cell differentiation. This article reviews the latest advances on the role of key components involved in the PI3K/AKT/ mTOR signaling pathway, including PI3 K, AKT, mTOR, FoxO and GSK-3 in HSC.