Hedgehog信号通路介导白血病干细胞耐药

Drug Resistance of Leukemic Stem Cells Mediated by Hedgehog Signaling Pathway

耐药与复发是当前急性白血病治疗的瓶颈,逆转白血病干细胞(LSC)耐药,清除体内残留LSC是治愈白血病的关键。近来研究发现,异常激活的Hedgehog(HH)信号通路在多种肿瘤发生发展中发挥重要作用,同时也是LSC产生多重耐药的关键机制之一。本文简要叙述HH信号通路介导LSC耐药的机制,为清除体内残留LSC提供新思路。

Drug resistance and relapse are the major challenge for current treatment of acute leukemia. It is critical for ultimately curing leukemia to overcome chemoresistance of leukemic stem cells （LSC） and to eradicate LSC. Recent studies have found that abnormal activated Hedgehog （HH） signaling pathway plays an important role in a wide variety of tumors and regulates multi-drug resistance of LSC. This review briefly summarizes the molecular mechanism of HH signal pathway inducing drug resistance of LSC and leading to novel strategies for eradicating LSC.