急性脑梗死患者外周血白介素-33水平的变化及其临床意义

Chang and its clinical significance of level of peripheral blood interleukin-33 in acute cerebral infarction patients

目的探讨急性脑梗死患者外周血白介素(IL)-33水平的变化及其临床意义。方法根据梗死体积将62例急性脑梗死患者分为大梗死组(22例)、中梗死组(20例)及小梗死组(20例),检测其外周血IL-33水平,并与15名健康对照者(正常对照组)比较。结果与正常对照组比较,大梗死组与中梗死组的血IL-33水平显著增高(P<0.05～0.01)。IL-33水平随着梗死体积增大而增高;大、中、小脑梗死组中两两比较差异有统计学意义(均P<0.05)。结论急性脑梗死患者的血IL-33水平升高,并且与脑梗死体积有关。

Objective To explore the change and its clinical significance of levle of peripheral blood interleukin （IL）-33 in acute cerebral infarction （ACI） patients. Methods According to the infarct volume, 62 ACI patients were divided into large infarct group （22 cases ）, medium infarct group （20 cases ） and small infarct group （20 cases）. The level of peripheral blood IL-33 was detected, and the results were compared with 15 normal controls （ normal control group）. Results Compared with normal control group, the level of blood IL-33 in large infarct group and medium infarct group were significantly higher （ P 〈 0. 05 - 0.01 ）. The level of IL-33 was increased with increasing infarct volume. Amony the large, medium and small groups, there was statistics significant difference in each two groups （ all P 〈 0. 05 ）. Conclusion The level of blood IL-33 is increased in ACI patients, and it is related to cerebral infarction volum.