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抑制性受体FcγRIIB的研究进展 被引量：3

Research progress of inhibitory IgG receptor FcγRIIB
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摘要 FcγRIIB作为一种抑制性受体,可介导对多种免疫细胞的负反馈调节反应,其可通过依赖或不依赖胞浆区免疫受体酪氨酸抑制基序ITIM的方式起到抑制细胞激活的作用。FcγRIIB在多种细胞上的异常表达可引发各种疾病,如自身免疫疾病、感染性疾病和肿瘤等。阐明FcγRIIB的生物学功能及与疾病间的联系,将有助于人们在治疗这些疾病方面找到新的靶点,进而提供一种有效的治疗方法。 As an inhibitory receptor, FcTRIIB mediates negative feedback regulation of many immunocytes. FcγRIIB can inhibit cell activation though immunoreceptor tyrosine-based inhibition motif （ITIM） or not. Anabnormal expression of FcγRIIB on cells would result in autoimmune diseases, infectious diseases, tumor and so forth. Further and comprehensive demonstration of the biological function of FcγRIIB and the relation with manydiseases can contribute to discovery of new target treatment for these diseases in future, and then provide effective methods for treating these diseases.
作者 秦三利 杨志伟
机构地区 宁夏医科大学基础医学院病原生物学与免疫学系
出处 《免疫学杂志》 CAS CSCD 北大核心 2013年第3期256-259,共4页 Immunological Journal
基金 国家自然基金(81160375) 宁夏医科大学博士启动金(XT200905)
关键词 FCΓRIIB 生物学功能 疾病 FcγRIIB Biological function Disease
分类号 R392.11 [医药卫生—免疫学]
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参考文献25

  • 1Cohen Solal JF, Cassard L, Fridman WH, etal. Fc gamma receptors[J]. Immunol Lett, 2004, 92(3): 199-205.
  • 2莫毅,王伟,梁方方,兰干球,郭亚芬,蒋和生.双磷酸化His-PZR蛋白的表达与分离纯化[J].免疫学杂志,2009(1):94-96. 被引量：1
  • 3姚忻,闻玉梅.抑制性IgG受体(FcγRIIB)的免疫调节作用及意义[J].生命科学,2009,21(1):49-52. 被引量：5
  • 4Reefman E, Dijstelbloem HM, Limburg PC, et al. Fc gamma receptors in the initiation and progression of systemic lupus erythematosus[J]. Immunol Cell Biol, 2003, 81(5): 382-389.
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  • 7Sohn HW, Pierce SK, Tzeng SJ. Live cell imaging reveals that the inhibitory Fc gamma RIIB destabilizes B cell receptor membrane-lipid interactions and blocks immune synapse formation[J]. J Immunol, 2008, 180(2): 793-799.
  • 8Blank MC, Stefanescu RN, Masuda E, et al. Decreased transcription of the human FCGR2B gene mediated by the -343 G/C promoter polymorphism and association with systemic lupus erythematosus[J]. Hum Genet, 2005, 117(2/3): 220-227.
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二级参考文献19

  • 1Van de Winkel JG, Capel PJ. Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications. Immunol Today, 1993, 14(5): 215-21
  • 2Budde P, Bewarder N, Weinrich V, et al. Tyrosine-containing sequence motifs of the human immunoglobulin G receptors FcRIIb 1 and FcRIlb2 essential for endocytosis and regulation of calcium flux in B cells. J B iol Chem, 1994, 269(48): 30636-44
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  • 8Tzeng S J, Bolland S, Inabe K, et al. The B cell inhibitory Fc receptor triggers apoptosis by a novel c-Abl-family kinase dependent pathway. J Biol Chem, 2005, 280(42):35247-54
  • 9Nimmerjahn F, Ravetch JV. Fc gamma receptors: old friends and new family members. Immunity, 2006, 24(1): 19-28
  • 10Sohn HW, Pierce SK, Tzeng SJ. Live cell imaging reveals that the inhibitory Fc RIIB destabilizes B cell receptor membrane-lipid interactions and blocks immune synapse formation. J Immunol, 2008, 180(2): 793-9

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免疫学杂志
2013年 第3期

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