2型糖尿病患者蛋白尿与糖尿病视网膜病变的关系

Relationship of albuminuria and diabetic retinopathy in type 2 diabetic patients

目的探讨2型糖尿病(T2DM)患者尿白蛋白/肌酐比值(UACR)与糖尿病视网膜病变(DR)的关系。方法 152例T2DM患者根据UACR均分为UACR正常(A)组(UACR<30mg/g)和UACR异常(B)组(UACR≥30mg/g),根据糖尿病病程再分为病程<10年(C)组(87例)和病程≥10年(D)组(65例)。检测血糖、糖化血红蛋白,计算UACR。结果 B组DR患病率53.9%,明显高于A组的28.9%(P<0.05),B组发生DR的危险是A组的2.875倍(95%可信区间为1.471-5.620)。C组中,UACR异常患者的DR患病率51.6%,明显高于UACR正常者的26.8%(P<0.05),且前者发生DR的危险是后者的2.916倍(95%可信区间为1.162-7.314)。结论病程较短且UACR异常的T2DM患者发生DR的风险较高。

Objective To investigate the association between the ratio of urinary albumin to creatinine（UACR） and diabetic retinopathy（DR） in patients with type 2 diabetes mellitus（T2DM）.Methods A total of 152 T2DM cases was equally assigned into two groups of A（UACR 30 mg/g） and B（UACR≥30 mg/g）,or divided into two groups of C（87 cases with T2DM 10 years） and D（65 cases with T2DM≥10 years）.Blood glucose（BG） and glycosylated hemoglobin（HbA1c） were measured and UACR was calculated.Results The incidence rate of DR was higher in group B than that of group A（53.9% vs.28.9%）（P0.05） and the DR risk of group B was 2.875 times as much as that of group A（95% confidence interval 1.471-5.620）.In group C,the incidence rate of DR was higher in the cases with UACR≥30 mg/g than those with UACR30 mg/g（51.6% vs.26.8%）（P0.05）,and the DR risk in the former was 2.916 times of the latter（95% confidence interval 1.162-7.314）.Conclusion The patients with T2DM 10 years and abnormal UACR have higher risk for DR.