期刊文献+

从生命科学领域解读《Science》2012年度十大突破

Breakthroughs of the 2012 year of 《Science》 in life science
下载PDF
导出
摘要 2012年12月20日,美国《Science》杂志公布了2012年度十大科学突破,领域涉及物理学、工程学、生命科学及其他科学。其中,生命科学领域的重要发现包括:"古人类DNA序列的完美呈现","基因组的巡航导弹","超越基因的基因组","X射线激光器测定蛋白质结构","脑机接口的成功应用"以及"干细胞诱导成为卵细胞"。本文主要针对这六项突破进行解读。 This year saw leaps and bounds in physics, along with significant advances in engineering, life science and many other areas. In keeping with tradition, Science’s editors and staff have selected a winner and nine runners-up. In this review, the following six breakthroughs in life science will be explained, including "a home run for ancient DNA", "genomic cruise missiles", "genomics beyond genes", "first protein structure from an X-ray laser", "brain-machine interfaces start to get a grip" and "making eggs from stem cells".
作者 张婷 王晓民
出处 《首都医科大学学报》 CAS 2013年第1期154-159,共6页 Journal of Capital Medical University
关键词 古人类DNA 转录激活子样效应因子核酸酶 DNA元件百科全书 蛋白质结构 脑机接口 干细胞 ancient DNA transcription activator-like effectors nucleases the encyclopedia of DNA elements protein structure brain-machine interface stem cell
  • 相关文献

参考文献26

  • 1Breakthrough of the year. The runners-up[J].Science,2012,(6114):1525-1532.
  • 2Green R E,Krause J,Briggs A W. A draft sequence of the Neandertal genome[J].Science,2010,(5979):710-722.
  • 3Meyer M,Kircher M,Gansauge M T. A high-coverage genome sequence from an archaic Denisovan individual[J].Science,2012,(6104):222-226.
  • 4Pennisi E. The tale of the TALEs[J].Science,2012,(6113):1408-1411.
  • 5Boch J,Scholze H,Schornack S. Breaking the code of DNA binding specificity of TAL-type III effectors[J].Science,2009,(5959):1509-1512.
  • 6Moscou M J,Bogdanove A J. A simple cipher governs DNA recognition by TAL effectors[J].Science,2009,(5959):1501.
  • 7Joung J K,Sander J D. TALENs:a widely applicable technology for targeted genome editing[J].Nature Reviews Molecular Cell Biology,2012,(01):49-55.
  • 8Hockemeyer D,Wang H,Kiani S. Genetic engineering of human pluripotent cells using TALE nucleases[J].Nature Biotechnology,2011,(08):731-734.
  • 9Carlson D F,Tan W,Lillico S G. Efficient TALEN-mediated gene knockout in livestock[J].Proceedings of the National Academy of Sciences(USA),2012,(43):17382-17387.
  • 10Bedell V M,Wang Y,Campbell J M. In vivo genome editing using a high-efficiency TALEN system[J].Nature,2012,(7422):114-118.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部