胎盘线粒体功能异常在子痫前期中的意义

Role of mitochondrial dysfunction in placenta of patients with preeclampsia

目的探讨胎盘线粒体功能障碍在子痫前期中的作用。方法选取正常妊娠、轻度子痫前期以及重度子痫前期孕妇各15例,对胎盘线粒体形态、膜电位、三磷酸腺苷(ATP)的含量及胎盘内活性氧(ROS)的含量等指标进行观察和检测。结果与正常组比较,轻度子痫、重度子痫组胎盘线粒体超微结构均有改变,膜电位和ATP含量显著降低,ROS升高。结论子痫前期胎盘组织线粒体功能异常可能参与子痫前期发病的重要环节。

Objective To investigate the role of mitochondrial dysfunction in the placenta of patients with preeclampsia.Methods The morphology,membrane potential,ATP content in mitochondria of the placenta and reactive oxygen species（ROS） content in the placenta were examined in 15 healthy term pregnant women,15 patients with mild preeclampsia and 15 patients with severe preeclampsia.Results Compared to the healthy term pregnant women,ATP activity and membrane potential in mitochondria were decreased and the content of ROS was increased in the placenta in the gravida with severe and mild preeclampsia.Conclusion The mitochondrial dysfunction of the placenta may be involved in the pathogenesis of preeclampsia.