降钙素原检测在脑卒中患者肺部感染的诊断价值

Significance of serum procalcitonin delection in the diagnosis of stroke-associated pulmonary infection

目的研究血清降钙素原(PCT)在脑卒中后肺部感染患者中的临床价值。方法测定42例脑卒中合并肺部感染患者(感染组)和40例单纯脑卒中患者(对照组)的血清PCT和C反应蛋白(CRP)水平,比较其组间差异。结果入院第1天和第4天,感染组PCT均明显高于对照组[(0.92±0.63)ng/ml vs.(0.18±0.08)ng/ml,(1.37±0.93)ng/ml vs.(0.14±0.07)ng/ml](P<0.01),感染组CRP也明显高于对照组[(12.73±7.49)mg/L vs.(7.12±4.51)mg/L,(13.33±6.67)mg/L vs.(8.22±4.67)mg/L](P<0.05)。PCT诊断肺部感染的敏感度和特异度均高于CRP(P<0.01)。结论血清PCT可以作为脑卒中患者合并肺部感染的诊断指标。

Objective To evaluate the significance of serum procalcitonin delection in the diagnosis of stroke-associated pulmonary infection.Methods On the 1st and 4th day after admission,serum procalcitonin（PCT） and C-reactive protein（CRP） were determined in 42 patients with stroke-associated pulmonary infection（group A）and 40 stroke patients without pulmonary infections（group B）.The results were compared brtween two groups.Results On the 1stand 4th day after admission,serum levels of PCT were higher in group A than those in group B [（0.92±0.63） ng/ml vs.（0.18±0.08） ng/ml and（1.37±0.93） ng/ml vs.（0.14±0.07） ng/ml]（P0.01）,so did serum levels of CRP [（12.73±7.49） mg/L vs.（7.12±4.51） mg/L and（13.33±6.67） mg/L vs.（8.22±4.67） mg/L]（P0.05）.The sensitivity and specificity of PCT in diagnosing pulmonary infection in stroke patients were higher than those of CRP.Conclusion Serum PCT can be regarded as a good diagnosis index in stroke-associated pulmonary infection.