摘要
TRPM通道是TRP通道超家族的一员。包括TRPM1至TRPM8八个成员,除TRPM4与TRPM5外,其余成员对Ca2+和Mg2+均具有一定通透性。其中TRPM1、TRPM2、TRPM3和TRPM8主要参与调控细胞Ca2+的平衡,而TRPM6和TRPM7是调控细胞Mg2+平衡的关键通道。TRPM家族成员分布广泛,调节机制各异,对于细胞钙/镁平衡等一系列生理功能具有重要调控作用。
Melastatin-related transient receptor potential （TRPM） channels belong to the transient receptor potential（TRP）channel superfamily. All the members are permeable to Ca2＋ and Mg2＋ except TRPM4 and TRPM5. TRPM1, TRPM2, TRPM3 and TRPM8 are regulators of Ca2＋ and magnesium homeostasis, TRPM6 and TRPM7 are key regulators of Mg2＋ homeostasis. TRPM channels are distributed widely and activated by multiple stimuli. They play fundmental role in regulating cellular calcium / magnesium homeostasis and other various cell biological processes.
出处
《基础医学与临床》
CSCD
北大核心
2013年第3期370-373,共4页
Basic and Clinical Medicine
基金
国家自然科学基金(81101344/HO604)
同济大学附属第十人民医院优秀青年人才培养计划(11RQ104)
