过氧化物酶体增殖物激活受体γ与肝脏疾病的关系

The correlation between peroxisome proliferator-activated receptor γ and liver diseases

过氧化物酶体增殖物激活受体γ（PPARγ）是一种属于配体激活核受体超家族的转录因子。PPARγ调节体内多种能量代谢，对脂类代谢及糖代谢尤为重要。此文综述PPARγ与非酒精性脂肪性肝病、肝纤维化、肝炎病毒、肝癌等肝脏疾病关系的最新研究进展，为肝脏疾病的治疗和研究提供一定的参考。

Peroxisome proliferator-activated receptor γ （PPARγ） is a transcriptional factor of ligand-activated nuclear receptor superfamily. PPARγ plays a critical role in regulating a series of energy homeostasis, especially for lipid and glucose metabofism. This article focuses on the current understanding of PPARγ and its impact on liver diseases, including non-alcoholic fatty liver disease, hepatic fibrosis, hepatic virus and hepatocellular carcinoma, to provide references for research and therapy of liver diseases.