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煤工尘肺壹期患者血清IL-17A、IL-17F和IL-22水平变化 被引量：1

Changes of IL-17A,IL-17F and IL-22 levels in patients with stageⅠcoal workers' pneumoconiosis
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摘要 目的探讨血清白细胞介素(IL)-17A、IL-17F和IL-22在煤工尘肺(CWP)壹期患者中的变化及作用。方法用酶联免疫吸附双抗体夹心法检测95例CWP壹期患者(CWP组)[其中52例单纯CWP患者,43例CWP并发症患者(分别并发慢性支气管炎、肺气肿、慢性阻塞性肺疾病)]、44例健康井下接尘矿工(接尘对照组)和37例井上健康人(正常对照组)血清中IL-17A、IL-17F和IL-22水平。结果与正常对照组和接尘对照组比较,CWP组血清IL-17A和IL-22均升高,差异均有统计学意义(P<0.05),IL-17F差异无统计学意义(P>0.05);单纯CWP患者与3种CWP并发症患者血清IL-17A、IL-17F和IL-22水平比较,差异均无统计学意义(P>0.05);CWP组IL-17A与IL-17F呈低度正相关(相关系数=0.298,P=0.032)。结论 IL-17A、IL-17F和IL-22与CWP壹期的发生发展有关,检测IL-17A和IL-22可能对协助CWP诊断有一定参考价值。
作者 袁宝军 周春英 李超 邹吉敏 王冬梅 高利常
机构地区 开滦总医院检验科 河北联合大学
出处 《中国职业医学》 CAS 北大核心 2013年第1期50-51,54,共3页 China Occupational Medicine
关键词 煤工尘肺 白细胞介素-17A 白细胞介素-17F 白细胞介素 22
分类号 R135.2 [医药卫生—劳动卫生]
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参考文献10

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二级参考文献9

  • 1李庆,李廷,祁新兰.煤工尘肺患者血清TNF-α、sIL-2R、IL-6和IL-8检测的意义[J].中国工业医学杂志,2006,19(1):11-12. 被引量：21
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中国职业医学
2013年 第1期

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