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Nrf2/HO-1通路在氧化损伤保护机制中研究进展 被引量：27

Research progress of Nrf2/HO-1 pathway in mechanism of oxidative damage and protection
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摘要 Nrf2[NF—E2（Nuclearfactor—erythroid2）relatedfactor2]属于转录因子亮氨酸拉链转录激活因子（CNC）家族成员，为细胞防御多种应激损伤的关键因子[1]。
作者 乔丽杰 王延让 张明
机构地区 天津中医药大学研究生院 天津市疾病预防控制中心
出处 《中国职业医学》 CAS 北大核心 2013年第1期82-84,共3页 China Occupational Medicine
基金 天津市科技支撑重点项目(11ZCGYSY02100) 天津市自然科学基金重点项目(07JCZDJC08500 09JCZDJC20900) 天津市卫生局基金项目(2012KY15)
关键词 NRF2 HO-1通路 氧化损伤 氧化保护 氧化应激
分类号 R135 [医药卫生—劳动卫生]
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参考文献22

  • 1JIAN Z,LI K,LIU L. Heme oxygenase-1 protects human melanocytes from H2O2-induced oxidative stress via the Nrf2-ARE pathway[J].Journal of Investigative Dermatology,2011,(07):1420-1427.
  • 2ESPADA S,ORTEGA F,MOLINA-JIJON E. The purinergic P2Y(13) receptor activates the Nrf2/HO-1 axis and protects against oxidative stress-induced neuronal death[J].Free Radical Biology and Medicine,2010,(03):416-426.
  • 3MA W,YUAN L,YU H. Genistein as a neuroprotective antioxidant attenuates redox imbalance induced by beta-amyloid peptides 25-35 in PC12 cells[J].International Journal of Developmental Neuroscience,2010,(04):289-295.
  • 4MCCUBREY J A,LAHAIR M M,FRANKLIN R A. Reactive oxygen species-induced activation of the MAP kinase signaling pathways[J].Antioxidants and Redox Signalling,2006,(9/10):1775-1789.
  • 5LI M,ZHANG X,CUI L. The neuroprotection of oxymatrine in cerebral ischemia/reperfusion is related to nuclear factor erythroid 2-related factor 2(Nrf2)-mediated antioxidant response:role of Nrf2 and heneoxygenase-1 expression[J].Biological and Pharmaceutical Bulletin,2011,(05):595-601.
  • 6SO H,KIM H,KIM Y. Evidence that Cisplatin-induced Auditory Damage is Attenuated by Downregulation of Pro-inflammatory Cytokines Via Nrf2/HO-1[J].Journal of the Association for Research in Otolaryngology,2008,(03):290-306.doi:10.1007/s10162-008-0126-y.
  • 7RYTER S W,MORSE D,CHOI A M. Carbon monoxide and bilirubin:potential therapies for pulmonary/vascular injury and disease[J].American Journal of Respiratory Cell and Molecular Biology,2007,(02):175-182.
  • 8PIANTADOSI C A,CARRAWAY M S,BABIKER A. Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1[J].Circulation Research,2008,(11):1232-1240.
  • 9MINK J,KIM J H,JOU I. Adenosine induces hemeoxygenasel expression in microglia through the activation of phosphatidylinositol 3-kinase and nuclear factor E2-related factor 2[J].Glia,2008,(09):1028-1037.doi:10.1002/glia.20676.
  • 10HSU C L,WU Y L,TANG G J. Ginkgo biloba extract confers protection from cigarette smoke extract-induced apoptosis in human lung endothelial cells:Role of heme oxygenase-1[J].Pulmonary Pharmacology and Therapeutics,2009,(04):286-296.

二级参考文献24

  • 1马丽,朱邦豪,陈健文,丘钦英,周家国,关永源.灯盏花素对糖尿病大鼠肾脏氧化应激的影响[J].中国药理学通报,2004,20(9):1030-1033. 被引量：52
  • 2杨晓,李彩蓉,朱忠华,苏华,卢远航.EGCG对实验性糖尿病大鼠肾脏的保护作用[J].中国药理学通报,2006,22(1):84-88. 被引量：18
  • 3Evans J L,Goldfine I D,Maddux B A,et al.Oxidative stress and stress-activated signaling pathways:a unifying hypothesis of type 2 diabetes[J].Endocr Rev,2002,23(5):599-622.
  • 4Ha H,Hwang I A,Park J H,Lee H B.Role of reactive oxygen species in the pathogenesis of diabetic nephropathy[J].Diabetes Res Clin Pract,2008,82(Suppl 1):S42-5.
  • 5Fattman C L,Schaefer L M,Oury T D.Extracellular superoxide dismutase in biology and medicine[J].Free Radic Biol Med,2003,35(3),236-56.
  • 6Xu G W,Yao Q H,Weng Q F,et al.Study of urinary 8-hydroxydeoxyguanosine as a biomarker of oxidative DNA damage in diabetic nephropathy patients[J].J Pharm Biomed Anal,2004,36(1):101-4.
  • 7Yu X,Kensler T.Nrf2 as a target for cancer chemoprevention[J].Mutat Res,2005,591:93-102.
  • 8Thimmulappa R K,Mai K H,Srisuma S.Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray[J].Cancer Res,2002,62(18):5196-203.
  • 9Agarwal A,Nick H S.Renal response to tissue injury:Lessons from heme oxygenase-1 gene ablation and expression[J].J Am Soc Nephrol,2000,11(5):965-73.
  • 10Shen G,Jeong W S,Hu R,Kong A N.Regulation of Nrf2,NF-kappaB,and AP-1 signaling pathways by chemopreventive agents[J].Antioxidant Redox Signal,2005,7(11-12):1648-63.

共引文献56

同被引文献294

引证文献27

二级引证文献102

中国职业医学
2013年 第1期

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