三元共聚物温敏性微凝胶的制备及性能研究

Study on preparation and properties of temperature-sensitive terpolymer microgels

以N-异丙基丙烯酰胺(NIPAM)、2-丙烯酰胺-2-甲基丙磺酸(AMPS)和N-叔丁基丙烯酰胺(NT-BA)为共聚单体,N,N-亚甲基双丙烯酰胺(MBA)为交联剂,过硫酸铵(APS)为引发剂,通过无皂乳液聚合的方法制备了一系列三元共聚物温敏性微凝胶。测定结果表明,所得微凝胶具有规则的球形结构且粒径分布均一,引入疏水性单体NTBA能有效调节共聚物微凝胶的低临界溶解温度(LCST),并对其药物负载与释放进行了初步探索。

A series of novel terpolymer microgels were synthesized by surfactant-free emulsion polymerization of N-isopropylacrylamide（NIPAM）,2-acrylamide-2-methylpropanesulfonic acid（AMPS） and N-tert-butylacrylamide（NTBA） using N,N-methylenebisacrylamide（MBA） as crosslinker in the presence of ammonium persulfate（APS） as initiator.The results showed that the terpolymer microgels had spherical structure and particle size was uniform based on the analysis of transmission electron microscopy（TEM）.It is find that reducing of the lower critical solution temperature（LCST） of terpolymer microgels with the increasing amount of hydrophobic monomer NTBA in feed.It means increasing NTBA can effectively adjust of the LCST of terpolymer microgels.And we make a preliminary exploration on the drug loading and release.