癫痫治疗新药氯巴占的药理与临床评价

Pharmacological and clinical evaluation of the antiepileptic drug clobazam

氯巴占为1,5-苯二氮类药物,具有抗癫痫作用,FDA于2011年10月21日批准其用于难治性癫痫———林-戈综合征(Lennox-Gastaut syndrome)的辅助治疗。本文通过Medline对氯巴占进行文献检索,并对其药理作用、药动学、药物相互作用、临床研究和安全性进行了综述。

Clobazam, a 1,5-benzodiazepine, possesses antiepileptic activity. It has been approved by the FDA for treatment of Lennox-Gastaut syndrome, one of the refractory epilepsies, in October 21th, 2011. Literature search was conducted by searching MEDLINE with the key words clobazam. The pharmacology, pharmacokinetics, drug interactions, clinical trials and side effects of clobazam were reviewed in this paper.