摘要
I型变态反应是临床上常见的一类困扰患者生活质量的疾病,严重的可致死。现有抗I型变态反应药物存在着各种问题,研制该类新药已成为国际各大制药公司的共同话题。本文将从新药研发的角度,围绕I型变态反应发病的细胞与分子生物学机制,就抗I型变态反应的药物可能的作用靶点及新药研发进展做一综述,并指出了未来5年的发展趋势。
Many patients suffer from a frequently occurred disease in clinic, type I hypersensitivity, which might cause death if it were serious. Because available drugs have various kinds of defects, the research and development of new drugs for type I hypersensitivity has been a common theme to international pharmaceutical companies. Focusing on the cellular and molecular biologic pathogenesis of type I hypersensitivity, this review summarized the possible action targets of drugs resisting type I hypersensitivity, and the progress on research and development of new drugs from the point of view on the new medicine research and development. This review also pointed out the progress tendency on research of the targets and new drugs in the coming five years.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2013年第4期417-421,446,共6页
Chinese Journal of New Drugs
关键词
I型变态反应
细胞与分子生物学机制
靶点
新药研究
发展趋势
type I hypersensitivity
cellular and molecular biologic pathogenesis
targets
new drugs development
progress tendency