摘要
肺损伤生物标志可在不同水平上反映肺细胞乃至呼吸系统对各种刺激产生的应答。肺细胞损伤生物标志有总蛋白、白蛋白、乳酸脱氢酶、γ-谷氨酰转移酶、N-乙酰氨基葡萄糖苷酶;炎症生物标志有肺泡灌洗液中收集的细胞、C反应蛋白、细胞因子、趋化因子;氧化应激生物标志有细胞外超氧化物歧化酶、铁结合蛋白、4-羟壬烯醛、F2-异前列腺素、血红素氧化酶-1;其他相关生物标志有呼出气体中的一氧化氮、不对称和对称二甲基精氨酸、表面活性蛋白、基质金属蛋白酶等。多种生物标志联合应用有助于肺部损伤诊断与治疗。以系统生物学理论为指导,综合运用各组学技术,寻找并验证肺损伤特征性生物标志是后续研究趋势。
Biomarkers of lung injury can reveal the responses of lung cells and respiratory system to various stimuli. Total protein, albumin, lactate dehydrogenase, γ-glutamyl transferase and N-acetyl glucosaminidase are the biomarkers of lung cell injury. Bronchoalveolar lavage ceils, C-reactive protein, cytokines and chemokines are lung inflammatory biomarkers. Extracellular superoxide dismutase, iron-binding protein, 4-hydroxynonenal, F（2） - isoprostanes and heme oxygenase-1 are oxidative stress biomarkers. There are other related biomarkers such as exhaled nitric oxide, asymmetric and symmetric dimethyl arginine, surfactant proteins and matrix metalloproteases. Combination of multiple biomarkers contributes to the diagnosis and treatment of lung injury. Guided by the theory of systems biology, comprehensive use of varied genomics technology is a follow-up research trends to find and verify characteristic biomarkers of lung injury.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2013年第4期429-432,459,共5页
Chinese Journal of New Drugs
基金
国家"重大新药创制"科技重大专项(2010ZXG0900X-005)
关键词
肺损伤
生物标志
炎症
氧化应激
支气管肺泡灌洗
lung injury
biomarker
inflammation
oxidative stress
bronchoalveolar lavage
