我院社区获得性肺炎患者抗菌药物治疗的回顾性分析

Retrospective analysis of the antibiotic treatment of CAP hospitalized patients in People's Hospital of Peking University

目的:回顾性分析北京大学人民医院2009年4月-2011年2月社区获得性肺炎(CAP)患者抗菌药物的治疗状况,以期为我院CAP患者合理使用抗菌药物提供依据。方法:采用药品用药频度(DDDs)和SPSS 13.0统计分析软件,对我院2009年4月-2011年2月住院治疗的CAP患者临床基本资料及抗菌药物使用情况进行统计和分析。结果:2009年4月-2011年2月我院住院CAP患者的平均住院日为13.32 d,老年患者的平均住院日显著长于中、青年患者。住院的CAP患者痰培养的送检率与阳性率分别为73.36%和33.12%。选用的经验性抗菌药物主要为β-内酰胺类、喹诺酮类和大环内酯类抗菌药物,其选用比率分别为20.37%,20.19%和12.52%。结论:2009年4月-2011年2月我院住院CAP患者痰培养率较高,但培养结果仍需要根据患者的临床体征辩证的分析。经验性抗感染治疗以β-内酰胺类、喹诺酮类和大环内酯类药物单用或联用为主,基本符合了我国《社区获得性肺炎诊断和治疗指南》中的推荐用药。

Objective ： To analyze the current antibiotic therapy for community-acquired pneumonia （CAP） in People＇s Hospital of Peking University from April 2009 to February 2011, and to provide the basis for clinical rational use of antibiotics. Methods： The data of hospitalized CAP patients from April 2009 to February 2011 were retrospectively analyzed by defined daily dosages （DDDs） and SPSS 13.0. Results： The average stay length of hospitalized CAP patients from April 2009 to February 2011 was 13.32 d. The elderly patient＇s average length of stay was longer than young and middle-aged patients. The submitted rate of sputum culture and the positive rate of patients were 73.3% and 33.12%. Empirical antibiotic therapy for CAP included β-lactam antibiotics （20. 37% ） , quinolones （20.19%） and macrolides （12.52%）. Conclusion： The rate of sputum culture of hospitalized CAP patients from April 2009 to February 2011 was high, but we need to judge the result of sputum culture in combination with patients＇ clinical signs. The empirical antibiotic therapy basically meets the guideline for Chinese CAP.