尼麦角林联合奥拉西坦治疗血管性认知障碍的疗效观察

Efficacy of Nicergoline Combined with Oxiracetam in Treatment of Vascular Cognitive Impairment

目的:探讨尼麦角林联合奥拉西坦治疗血管性认知功能障碍患者的临床疗效。方法:选取选血管性认知功能障碍患者108例,将其随机分为尼麦角林组、奥拉西坦组及联合治疗组,共治疗24周,对比治疗前后各组的MMSE量表及ADL评分,评价3组疗效。结果:各组患者在治疗后认知功能及生活能力评分较治疗前均有提高,差异均有统计学意义(P<0.05),而联合治疗组的疗效优于两外两组,差异具有统计学意义(P<0.05)。结论:尼麦角林及奥拉西坦均可以改善血管性认知障碍患者的认知功能和生活能力水平,如果两种药物联合应用,则临床效果更加明显。

Objective ：To investigate the efficacy of nicergoline and oxiracetam in treatment of patients with vascular cog- nitive impairment. Methods ：108 patients with vascular cognitive impairment were randomly divided into 3 groups, one of them treatd with nicergoline, another treated with oxiraeetam, the 3th group treated with both of nicergoline and oxirace- tam. MMSE and ADL Scale of all groups were assessed and compared before and after 24 weeks treatment. Results： MMSE and ADL Scale of all groups have been higher after treatment （ P 〈 0. 05 ） , And the combine medicine group has higher scale than other two groups （ P 〈 0. 05 ）. Conclusions ： Both of nicergoline and oxiracetam can improve cognitive function and behavioral ability in patients with vascular cognitive impairment. And Combination of oxiracetam and nicerg- olin have better efficacy.