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非酮症性糖尿病性癫痫的循证治疗 被引量:1

Evidence-Based Treatment of A Nonketotic Diabetic Patient with Epilepsy
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摘要 目的针对收治的1例少见的非酮症性糖尿病性癫痫患者,检索当前最佳证据,为临床合理治疗提供依据。方法计算机检索Cochrane图书馆(2011年第4期)、PubMed(1966年至2012年4月)、EMBASE(1974年至2012年4月)、CBM(1978年至2012年4月)、CNKI(1979年至2012年4月),按证据级别高低查找相关证据,并对所获证据进行评价。结果共检索到316篇文献,无临床指南和系统评价,也无临床对照研究。有关临床治疗的文献共有65篇,包括3种治疗方案,结合患者意愿,给予小剂量胰岛素控制血糖、补液、改善微循环、预防脑水肿,血糖水平趋于平稳,未见癫痫样抽搐发生。随访8个月,血糖控制好,未见癫痫样抽搐发作。结论早期诊断非酮症性糖尿病性癫痫可避免漏诊、误诊,改善预后。 Objective To identify the best therapeutic regimen for a rare nonketotic diabetic patient with epilepsy. Methods We searched the Cochrane Library (Issue 4, 2011), PubMed (1966 to April 2012), EMBASE(1974 to April 2012), CBM (1978 to April 2012) and CNKI (1979 to April 2012) to identify relevant evidences. The quality of the retrieved studies was critically assessed. Results A total of 316 records were retrieved. No clinical guidelines, systematic reviews or clinical randomized studies were identified. According to sixty-five treatment-related literatures involved 3 interventions, combined with the patient preference, small doses insulin was given to control blood sugar and fluid infusion, with improved microcirculation and prevention of cerebral edema, blood sugar levels gradually stabilized, and there was no occurrence of epileptic seizures anymore. Follow-up of 8 months, blood glucose was under control and no more epileptic seizures relapse. Conclusion Early diagnosis of nonketotic diabetes epilepsy could prevent the misdiagnosis and improve clinical outcome.
出处 《循证医学》 CSCD 2013年第1期54-56,共3页 The Journal of Evidence-Based Medicine
关键词 糖尿病 癫痫 抽搐 循证治疗 diabetes mellitus epilepsy seizure evidence-based treatment
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