角鲨烯软胶囊提高缺氧耐受力的研究

Study on the Effects of Squalene Softgel on Enhancing Anoxia Endurance Function

为研究角鲨烯软胶囊的保健功能,以角鲨烯油为原料,将小鼠按体重随机分为推荐剂量的10倍、20倍、30倍剂量组和对照组,连续灌胃给予角鲨烯30 d,采用常压耐缺氧法、亚硝酸钠中毒致死法及急性脑缺血性缺氧法分别记录小鼠耐缺氧存活时间、亚硝酸钠中毒存活时间及急性脑缺血后喘气时间。结果表明,20倍、30倍剂量组常压缺氧时间和亚硝酸钠中毒存活时间延长;在急性脑缺血性缺氧条件下,3个剂量组均能延长喘气时间,与对照组相比,差异有统计学意义(P<0.05),且对小鼠体重增长无影响。说明角鲨烯软胶囊作为保健食品具有提高小鼠缺氧耐受力的作用。

in order to study the effects of squalene softgel on enhancing anoxia endurance function, mice were randomly divided into groups with 10 times - ,20 times - ,and 30 times -dosage of the recommended level and con- trol group, and then squalene softgel was orally given to them in three dosage groups for 30 consecutive days. And then we recorded the survival time of mice exposed to hypoxia under the normal pressure, with sodium nitrite poisoning and after acute cerebral ischemia in three corresponding methods respectively. As the results showed, mice, which were ex- posed to hypoxia under the normal pressure and with sodium nitrite poisoning in 20 times - and 30 times - dosage groups, survived longer than those in control group, at the same time, mice with acute cerebral ischemia in all dosage groups survived longer than those in control group;compared with the result in control group, the differences were sta- tistically significant （P 〈0. 05 ） and had no influence on mice bodyweight growth. It was proved that squalene softgel, as the functional food, could enhance anoxia endurance function of mice.