摘要
伴或不伴腭裂的唇裂(简称CL(P))与遗传密切相关。为了探讨其遗传方式,我们对288例CL(P)住院病人进行了家系调查。研究表明,北京地区CL(P)的平均遗传度为58％。而由同胞患病率推算出的遗传度高达87％。三级亲属本病患病率的水平,以及各种类型(例:男、女;单、双侧裂)唇裂先证者亲属患病率的比较结果,均支持CL(P)多基因阈值遗传学说。
Cleft lip with or without cleft palate (CL±CP) is heritable. We studied the genetic pat-terns of the clefts in pedigree surveys of inpatients with CL±CP. The results indicated thatthe average heritability of siblings was increased to 87%. The results of the CL±CP prevalen-ces of relatives of three degrees and that of various types of probands all supported CL±CP asa disease of multigenic threshold inheritance.
出处
《北京医科大学学报》
CSCD
1991年第1期22-25,共4页
Journal of Peking University(Health Sciences)
关键词
唇裂
遗传学
腭裂
遗传度
多基因
Cleft lip (total)
Heritability Multigenic threshold inheritance
