某二级医院住院患者2010-2012年抗菌药物使用强度分析

AUD of Antibacterials in the Inpatients from a Secondary Hospital from 2010 to 2012

目的:了解某二级医院住院患者2010-2012年抗菌药物的使用强度(AUD)。方法:从该院药库计算机管理软件系统中查询2010-2012年抗菌药物的应用情况,对各种抗菌药物的AUD等数据进行统计、分析。结果:该院住院患者各年度抗菌药物的AUD分别为71.25、68.78、62.95DDDs/100人/天,呈稳步下降趋势。其中,青霉素类和第1、2代头孢菌素类的AUD均逐年降低,而大环内酯类、氨基糖苷类、硝基咪唑类的AUD则逐年上升,尤其是第3、4代头孢菌素类和其他β-内酰胺类的AUD增长迅速。结论:该院抗菌药物应用仍存在一些问题,特别是第3、4代头孢菌素的AUD增加过快,医院管理部门需进一步加强其临床应用监管。

OBJECTIVE： To investigate the AUD of antibacterials in the inpatients from a secondary hospital during 2010-2012. METHODS： The application of antibacterials in the hospital during 2010-2012 was inquired from management software system, and AUD of antibacterials was analyzed statistically. RESULTS： AUD of antibacterials by the hospitalized patients in three years were 71.25, 68.78 and 62.95 DDDs/100 persons/day, in decreasing manner. AUD of penicillin and first and second-generation cephalosporin decreased year by year, while that of macrolide, aminoside and nitroimidazole increased year by year, especially that of third and fourth-generation cephalosporin and other β-lactams increased quickly. CONCLUSIONS： There are some problems about use of antibacterials in the hospital; it is urgent for our hospital to tighten monitoring on the use of antibacterials because AUD of third and fourth-generation cephalosporin increase too fast.