子宫内膜异位症患者血清MMP-9、TIMP-1表达及红藤方的干预研究

Study on Serum MMP-9 and TIMP-1 Levels in Endometriosis by Caulis Sargentodoxae Formula

目的探讨子宫内膜异位症患者采用红藤方治疗的临床疗效及血清MMP-9、TIMP-1及其比值的变化。方法经腹腔镜手术确诊为子宫内膜异位症的患者90例随机分为3组即红藤方组、米非司酮组和对照组,观察3组的临床疗效,并于术前及药物治疗3月后分别测定血清MMP-9和TIMP-1水平。结果与对照组比较,红藤方组和米非司酮组总有效率明显提高(P<0.05),且后2者治疗后MMP-9水平明显降低,TIMP-1水平显著提高,与前者相比差异均具有统计学意义(P<0.01)。MMP-9/TIMP-1比值3组治疗前后均显著降低,且治疗后红藤方组和米非司酮组与对照组比较下降更明显,差异具有统计学意义(P<0.05)。结论红藤方可能通过调节MMP-9/TIMP-1的平衡而纠正盆腔内环境,有效改善子宫内膜异位症患者的临床症状。

OBJECTIVE To study the clinical value of laparoscopic operation combined with Caulis Sargentodoxae Formula on endometriosis. METHODS Ninety cases diagnosed endometriosis who were underwent laparoscopic operations were divided into three groups at random, 30 cases were treated with Caulis Sargentodoxae Formula as the Caulis Sargentodoxae Formula group, 30 cases were treated with mifepristone as the mifepristone group, the other 30 cases as the control group. RESULTS The total effective rate was significantly higher in the Caulis Sargentodoxae Formula group and in the mifepristone group than that of in the control group （P〈0.05）. After treatment, serum MMP-9 level was significant lower and serum TIMP-1 level was significant higher in the Caulis Sargentodoxae Formula group and in the mifepristone group than that of in the control group. The ratio of MMP-9/TIMP-1 was also significant lower in the Caulis Sargentodoxae Formula group and in the mifepristone group than that of in the control group（P〈0.05）. CONCLUSION Caulis Sargentodoxae Formula can significantly relieve the symptoms and signs of patients with endometriosis and improve inner environment of pelvic cavity by regulate the ratio of MMP-9/TIMP- 1.