摘要
目的研究葛根素对糖尿病肾病(DN)大鼠降钙素基因相关肽(CGRP)的影响。方法链脉佐菌素(STZ)诱导糖尿病大鼠模型,随机分为糖尿病组(D组)、葛根素治疗组(S组),同时另设正常对照组(CN组),给药干预14周后,测定空腹血糖(FBG)、尿微量白蛋白(U-mAIb)、血浆内皮素(ET)和CGRP含量。结果糖尿病大鼠UAER增加,ET升高,CGRP下降,给予葛根素治疗14周后,S组DN大鼠U-mAIb较D组显著降低,ET显著下降,CGRP明显升高。结论葛根素对糖尿病大鼠肾脏病变有一定的保护作用,其部分机制可能是通过上调CGRP含量而实现的。
Objective To investigate the effect of Puerarin on calcitonin gene-related peptide in diabetic nephropathy （DN） rats. Methods STZ-indueed diabetic rats were randomly divided into two groups： DN rats model group （D group）, puerarin treatment group （S group）, in addition, normal rats for control group （CN group）. All rats were fed for 14 weeks. The serum FBG, U-mAIb, ET and CGRP were measured. Results Compared with CN group, The content of U-mAIb and ET in DN rats were significantly increased. The level of CGRP was markedly decreased; After the Puerarin treatment, the serum CGRP, ET and U-mAIb changes of diabetic rats in the S group were improved. Conclusion Puerarin could meliorate early kidney hy-perdynamic abnormality in DN rats, possess protective effect on kidney of diabetic rat whose mechanism may be associated partly with a UP-regulation of the CGRP level.
出处
《中国当代医药》
2013年第7期7-8,13,共3页
China Modern Medicine
基金
江西师范大学青年成长基金(No.2399)
江西省亚热带植物资源保护与利用重点实验室基金部分资助项目
关键词
葛根素
糖尿病肾病
降钙素基因相关肽
大鼠
Puerarin
Diabetic nephropathy
Calcitonin gene-related peptide
Rats
