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糖尿病足感染伤口渗液中基质金属蛋白酶2和金属蛋白酶2组织抑制因子的定量研究 被引量：6

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摘要 应用ELISA法测定20例糖尿病足溃疡并感染患者(DF组)、10例糖尿病非感染手术患者(DM组)、及10例非糖尿病非感染手术患者(NC组)创面渗液样本中MMP-2、TIMP-2的浓度,并进行相关分析。结果 DF组渗液中MMP-2浓度显著高于DM组及NC组(P<0.05);DF组渗液中TIMP-2浓度低于DM组及NC组(P<0.05);DF组MMP-2/TIMP-2比值明显高于DM组及NC组(P<0.01),而DM组与NC组之间的差异不具有统计学意义(P>0.05);DF分组中混合感染组MMP-2的浓度较单一感染组升高(P<0.05),两组间TIMP-2的浓度及MMP-2/TIMP-2比值差异没有统计学意义(P>0.05);Ⅲ级溃疡组MMP-2的浓度及MMP-2/TIMP-2比值较Ⅱ级溃疡组升高(P<0.05),两组间TIMP-2的浓度差异没有统计学意义(P>0.05)。结论糖尿病足溃疡合并感染创面中MMP-2的浓度明显升高,TIMP-2的浓度明显下降,MMP-2/TIMP-2比值明显升高。
作者 叶林 肖正华 陈定宇
机构地区 广东省广州市第一人民医院内分泌科
出处 《实用糖尿病杂志》 2013年第1期48-50,共3页 Journal of Practical Diabetology
关键词 基质金属蛋白酶2 金属蛋白酶2组织抑制因子 糖尿病足溃疡 细菌感染
分类号 R587.2 [医药卫生—内分泌]
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参考文献9

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同被引文献58

  • 1王淑然,叶俊杰,龙琴.负透镜诱导豚鼠离焦性近视眼后部巩膜Ⅰ型胶原、基质金属蛋白酶-2及金属蛋白酶组织抑制因子-2的表达[J].中国医学科学院学报,2010,32(1):55-59. 被引量：18
  • 2李福伦,李斌,王振宜,徐蓉,范斌,徐文彬,金伟,肖秀丽,王一飞.SD大鼠糖尿病创面与正常创面中TGF-β1、TGF-β3的表达差异[J].中国美容医学,2007,16(1):35-37. 被引量：10
  • 3Menghini R,Uccioli L,Vainieri E,et al.Expression of tissue inhibitor of metalloprotease3is reduced in ischemic but not neuropathic ulcers from patients with type2diabetes mellitus[J].Acta Diabetol,2013,50(6):907.
  • 4Izzo V,Meloni M,Vainieri E,et al.High Matrix Metalloproteinase Levels Are Associated With Dermal Graft Failure in Diabetic Foot Ulcers[J].Int J Low Extrem Wounds,2014,13(3):191.
  • 5Li Z,Guo S,Yao F,et al.Increased ratio of serum matrix metalloproteinase-9against TIMP-1predicts poor wound healing in diabetic foot ulcers[J].J Diabetes Complications,2013,27(4):380.
  • 6Ambrosch A,Halevy D,Fwity B,et al.Effect of Daptomycin on Local Interleukin-6,Matrix Metalloproteinase-9,and Metallopeptidase Inhibitor1in Patients With MRSAInfected Diabetic Foot[J].Int J Low Extrem Wounds,2013,12(2):100.
  • 7Ambrosch A,Halevy D,Fwity B,et al.Effect of Daptomycin on Local Interleukin-6,Matrix Metalloproteinase-9,and Metallopeptidase Inhibitor1in Patients With MRSAInfected Diabetic Foot[J].Int J Low Extrem Wounds,2014,13(1):12.
  • 8Wukich DK,Armstrong DG,Attinger CE,et al.Inpatient Management of diabetic foot disorders:a clinical guide[J].Diabetes Care,2013,36(9):2862-2871.
  • 9Malik N,Shinde V.Antibiotic susceptibility patterns of pathogens isolated from diabetic foot ulcers[J].J Em Biol,2013,1(2):49-57.
  • 10Uzun G,Onem Y,Hatipoglu M,et al.Piperacillin/tazobactam-induced neutropenia,thrombocytopenia,and fever during treatment of a diabetic foot infection[J].Scand J Infect Dis,2013,45(1):73-76.

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实用糖尿病杂志
2013年 第1期

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