氩氦刀冷冻消融术治疗180例肝癌临床分析

Clinical analysis on 180 cases with argon helium cryoablation in treatment on liver carcinoma

目的探讨氩氦刀冷冻消融术治疗肝癌方法的安全性和近期疗效。方法选择180例肝癌患者在超声引导下行经皮穿刺氩氦刀冷冻治疗。术后定期复查肿瘤标志物及CT或MRI随访。结果小肝癌(≤5cm)患者135例,85%达到完全消融。大肝癌(>5cm)患者45例,治疗后AFP降至正常范围或CT、MRI提示肿瘤完全坏死21例,占46.8%。转移性肝癌44例,治疗后肿瘤标志物降至正常或CT、MRI提示完全坏死30例,占68.2%。结论超声引导下肝癌的经皮穿刺氩氦刀冷冻消融术是一种安全、有效的治疗方法。

Objective To explore the methods, safety and clinical results of argon-helium cryoablation therapy on liver carcinoma. Methods Total of 180 cases with liver carcinoma were selected to undergo argon-helium cryoablation therapy under ultrasound guidance and received periodic reviews of carcinoma marker and CT or MRI following up. Results Eighty five percent of 135 patients with small liver carcinoma （≤ 5 cm） were in complete necrosis after therapy. Among the 45 patients with large hepatocellular carcinoma, all AFP reached the normal range, 21 （48.6% of the total samples） were in complete tumor necrosis with the proof of CT or MRI examinations. CT or MRI proved that 30 of 44 （68.2%） patients with metastatic hepatic carcinoma were in complete necrosis after therapy. Conclusions Argon-helium cryoablation therapy under ultrasound guidance is safe and effective.