中国的精神分裂症转化医学研究进展

Translational research for schizophrenia in Chinese

无论是从病因学还是从临床特征上看,精神分裂症都为最复杂的一种精神疾病。然而,经过多年对其的研究,在发病机制方面仍未能取得突破性进展。近年来越来越受到关注的转化医学无疑将会为解决精神分裂症的临床医疗问题注入一剂强心剂,将会着重体现在对疾病的个体化诊断与治疗、早期识别与干预、环境因素的作用与鉴别等方面,以及用多学科交叉研究手段加深对疾病的综合治理。针对这些内容,本文就中国精神分裂症转化医学的研究现状及今后的发展做一概述。

Schizophrenia is one of the most complex psychotic disorders.Despite years of research,the fundamental nature of schizophrenia remains elusive.Recently,advances in the translarional research make researchers begin to rethink the approaches they used for schizophrenia.The basic research which has been focusing on genetic mechanism is turning to integrate the need of clinical diagnosis and treatment.Research emphasis thus will be put on the study of early diagnosis,personalized treatment,environmental risks identification and prevention of schizophrenia.This review will introduce the recent advances and future studies of translarional research of schizophrenia in China in these aspects.