小剂量激素辅助治疗小儿肺炎支原体肺炎的临床疗效观察

Clinical observation on lowdoses of glucocorticoid in the assistance treatment of mycoplasmal pneumonia

目的观察小剂量激素辅助治疗小儿肺炎支原体肺炎的临床疗效。方法118例确诊为肺炎支原体肺炎患儿随机分为两组；治疗组61例（应用小剂量激素），对照组57例（同期住院未用激素治疗）。患儿均常规给予止咳、平喘、雾化吸人等综合治疗，并且应用大环内酯类药物包括红霉素或阿奇霉素行抗感染治疗。治疗组加用地塞米松0．2～0．3mg·kg^-1·d^-1静脉滴注或口服泼尼松片0．5-1．0mg·kg^-1·d^-1，疗程3～5d。观察两组患儿发热及咳嗽缓解时间、肺部哕音消失时间。结果治疗组发热及咳嗽缓解时间、肺部哕音消失时间均短于对照组（t=-6．36、-2．04、-7．91，均P〈0．05）。结论小剂量糖皮质激素辅助治疗小儿肺炎支原体肺炎疗效较好，可常规应用于临床。

Objective To evaluate the clinical effects of low-dose glucocorticoid hormone adjuvant treatment for mycoplasma pneumonia. Methods 118 cases diagnosed with mycoplasma pneumonia were randomly divided into two groups, including conventional treatment group （61 cases） and hormone treatment group （57 cases）. The treat- ment group was given to the small dosage hormone, the control group was hospitalized for the same time which had not used the hormone the trouble. Both of two groups were given relieve a cough, breathe heavily evenly, the atomization inspiration and so on the complex therapy, and application large ring lactone class medicine including erythromycin or arch mildew element anti-infection treatment. On the basis of conventional treatment, the hormone treatment group was added with intravenous infusion of dexamethasone or oral prednisone. Compared with two groups of curative effects in- dexes including the defervescence time,the cough remission time, the moist crackles disappearance time and the hos- pitalization time. Results The defervescence time, the cough remission time, the moist crackles disappearance time and the hospitalization time were significantly lower in the hormone treatment group than those of the control group （t = - 6.36, - 2.04, - 7.91, all P 〈 0.05 ）. Conclusion Low-dose glucocorticoid hormone adjuvant treatment could have the better curative effects for mycoplasma pneumonia for children.