急性一氧化碳中毒患者血浆D-二聚体水平与迟发性脑病的相关性研究

The investigation on the correlation between plasma D-dimer with delayed encephalopathy in patients with acute carbon monoxide poisioning

目的探讨急性一氧化碳中毒（ACOP）患者血浆D-二聚体水平与迟发性脑病（DE）的相关性。方法将100例ACOP患者根据病情程度分为轻度组（27例）、中度组（31例）和重度组（42例），另外根据是否出现DE分为DE组（20例）和无DE组（80例）。采用免疫比浊法分别于入院后第1、7、14天抽血检测各组患者血浆D-二聚体水平，并进行分析。结果轻度组不同时间点血浆D-二聚体水平波动在正常范围内，差异均无统计学意义（均P〉0．05）；重度组与中度组血浆D-二聚体水平明显高于轻度组（均P〈0．01），均在第1周（7d）达到高峰，第2周（14d）后呈下降趋势。DE均发生在中、重度组。DE组D-二聚体水平从入院到第7、14天均高于无DE组（均P〈0．01）。结论动态监测血浆D-二聚体含量有助于评估ACOP的病情程度及预后，对于DE的预防和治疗具有积极的临床意义。

Objective To investigate the correlation between plasma D-dimer with delayed encephalopathy （DE） in patients with acute carbon monoxide poisioning（ACOP）. Methods According to the severity of disease, 100 patients with ACOP were divided into mild group （ 27 cases ）, moderate group （ 31 cases ）, severe group （ 42 cases）. And depending on whether DE oecured, all patients were divided into DE group（ 20 cases） and no DE group （80 cases）. 4 venous blood samples were obtained separately from each subject in 1,7,14 days after their admission to hospital by using latex immunoturbidimetry. The levels of blood plasma D-dimer of patients in each group were de- tected by immune turbidimetry and analyzed, l th, 7th and 14th day after admission. Results The plasma D-dimer level of the mild group at different time points was in the normal range, and the difference was not statistically signifi- cant（ all P 〉 0.05 ） ;The plasma D-dimer level of the severe group and moderate group was significantly higher than that of the mild group （ all P 〈 0.01 ） , and it reached a peak in one week （ 7 days ） , and showed a downward trend after two weeks（ 14 days）. The DE all occurred in the moderate and severe group. The plasma D-dimer levels of the DE group were higher than those of no DE group from admission to the 7 th and 14 th day （ all P 〈 0. 01 ）. Conclusion The dynamic monitoring plasma D-dimer is helpful in assessing to the severity and prognosis of ACOP, and could surpport positive clinical significance for the prevention and treatment of DE.