氟哌噻吨-美利曲辛联合美托洛尔治疗心脏神经症的临床观察

Clinical observation on flupentixol and melitracen combined with metoprolol in the treatment of patients with cardiac neurosis

目的探讨氟哌噻吨．美利曲辛联合美托洛尔治疗心脏神经症临床疗效。方法将57例心脏神经症患者随机分为对照组和治疗组。所有患者给予谷维素治疗，对照组加用美托洛尔治疗，治疗组则在对照组基础上加用氟哌噻吨-美利曲辛进行治疗，观察并比较两组临床疗效、汉密尔顿焦虑量表（HAMA）及汉密尔顿抑郁量表（HAMD）评分。结果治疗组总有效率为96．67％，显著高于对照组的85．19％（X^2=21．814，P〈0．05）；两组患者治疗后HAMA及HAMD评分均显著降低（均P〈0．05），但治疗组降低更为显著（均P〈0．05）。结论氟哌噻吨．美利曲辛联合美托洛尔治疗心脏神经症疗效肯定，值得临床推广。

Objective To explore the clinical effect of flupentixol and melitracen combined with metoprolol in the treatment of patients with cardiac neurosis. Methods 57 patients with cardiac neurosis were divided into the control group and treatment group randomly. The control group received therapy of metoprolol and oryzanol;The treat- ment group received additional therapy of flupentixol and melitracen based on treatment of the control group. Clinical effect, scores of HAMD and HAMA were observed and compared between the two groups. Results The total efficient rate of the treatment group was 96.67%, and significantly higher than that of the control group （ 85.19% ） （ X2 = 21. 814 ,P 〈 0. 05 ） ; HAMA and HAMD scores decreased significantly in all patients after treatment （ all P 〈 0. 05 ）, more significantly in the treatment group than those in the control group（ all P 〈 0.05 ）. Conclusion Flupentixol and melitracen combined with metoprolol in the treatment of patients with cardiac neurosis has good effect, which is worthy of clinical application.