复发、难治性多发性骨髓瘤的治疗策略

Treatment strategies for relapsed/refractory multiple myeloma

多发性骨髓瘤（MM）是一种不可治愈的恶性浆细胞疾病。虽然靶向治疗和干细胞移植的广泛应用，显著提高了MM的缓解率及延长了生存期，但治疗的疗效仍难以长期维持，几乎所有的患者最终都会出现复发及耐药。在复发时，如何为每例患者选择合理的治疗方案仍然是一个挑战，疾病和患者双方特点都需要加以考虑。

Multiple myeloma is a malignancy of plasma cells,which is still incurable now. Despite dramatic improvement of the response rate and overall survival have been made due to the application of target therapy and stem cell transplantation, the treatment effect is difficult to maintain,nearly all patients will eventually relapse and become refractory.At relapse, the challenge is to select the appropriate treatment for each patient. The decision will be both disease-dependent and patient-dependent.