摘要
目的:观察艾司西酞普兰与西酞普兰治疗抑郁症的疗效及安全性。方法:将42例抑郁症患者随机分为艾司西酞普兰组20例(艾司西酞普兰治疗)和西酞普兰组22例(西酞普兰治疗),疗程6周。于治疗前及治疗l、2、4和6周分别采用17项汉密尔顿抑郁量表(HAMD)和治疗中出现的症状量表(TESS)评定疗效和不良反应。结果治疗6周,艾司西酞普兰组和西酞普兰组的HAMD总分分别从治疗前(23.06±2.22)分和(22.78±2.03)分降至(7.76±2.98)分和(7.90±3.11)分;两组有效率分别为80.0%和77.3%(χ2=0.046,P=0.830),痊愈率分别为50.0%和45.5%(χ2=1.828,P=0.176)。两组间不良反应差异无统计学意义(P>0.05)。结论:艾司西酞普兰与西酞普兰抗抑郁疗效相同,但艾司西酞普兰起效更快。
Objective: To evaluate the efficacy and safety of escitalopram for depressive patients. Method : Forty-two depressive patients were randomized into eseitalopram group ( n = 20) and citalopram group ( n = 22) for a 6 weeks double-blind study. 17 items HAMD and treatment emergent symptoms scale were used to assess the effectiveness and safety before treatment and by the end of 1,2,4, and 6 weeks. Results: After 6 weeks of treatment, the HAMD scores decreased from ( 23.06 ± 2.22 ) and ( 22.78 ± 2.03 ) to ( 7.76 :l: 2.98 ) and (7.90 ±3.11 ) in the escitalopram group and the citalopram group respectively, the effective rate was 80.0% and 77.3% , and the curative rate was 50.0% and 45.5%. There was no significant difference in the effective and curative rate between the 2 groups ( X2 = 0. 046 ,P = 0.830 ; X2 = 1. 828 ,P = 0. 176). No significant differ- ence was found in main side effects between the 2 groups ( P 〉 0.05 ). Conclusion : Escitalopram and citalo- pram are similarly effective and safe in the treatment of depression, but escitalopram has earlier response.
出处
《临床精神医学杂志》
2013年第1期37-38,共2页
Journal of Clinical Psychiatry