较低剂量氯氮平合并阿立哌唑对精神分裂症患者体质量及糖脂代谢的影响

Effect of lower dose clozapine plus aripiprazole on body weight,glucose and lipid metabolism in patients with schizophrenia

目的:探讨较低剂量氯氮平合并阿立哌唑对精神分裂症患者体质量及糖脂代谢的影响。方法:选取2008年3月至2010年3月我院住院精神分裂症患者92例,随机分为研究组和对照组,研究组给予较低剂量氯氮平合并阿立哌唑治疗,对照组给予单纯氯氮平治疗。两组观察疗程24周。两组患者分别在治疗前、治疗12周及24周对其体质量、身高、血糖、餐后2h血糖、三酰甘油及胆固醇进行测定,并做统计分析。结果:与对照组相比,研究组治疗前后体质量及糖脂代谢变化显著较小(P均<0.01)。研究组体质量、血糖及三酰甘油异常率明显低于对照组(P均<0.01)。结论:较低剂量氯氮平合并阿立哌唑治疗与单用较高剂量氯氮平相比,对精神分裂症患者体质量及糖脂代谢影响较小。

Objective： To investigate effect of the lower dose of clozapine plus aripiprazole on body weight, glucose and lipid metabolism in patients with schizophrenia. Method ：92 schizophrenic patients from our hospital March,2008 to March,2010 were randomly divided into study group and control group, the study group was given a low dose clozapine combined with aripiprazole and the control group was given clozapine treat- ment for 24 weeks. The body mass, height, blood glucose,postprandial 2 hour blood glucose, cholesterol and tri- glyceride were measured before treatment, week 12 and 24. Results：Compared with the control group, the study group showed fewer changes on body weight and metabolism of glucose and lipid between before and after the treatment （ all P 〈 0.01 ）, and abnormal rates of body mass, glucose and triglyceride （ all P 〈 0.01 ）. Conclusion： Lower dose clozapine plus aripiprazole have less impact on the body mass and glucose metabolism than only high doses clozapine in the treatment of schizophrenia.