摘要
目的调查评估慢性肾脏病(chronic kidney disease,CKD)患者健康相关的生活质量,并探讨可能影响CKD患者健康相关生活质量的因素。方法应用欧洲五维健康量表(The EuroQol Group's 5-domain 3 level questionnaire,EQ-5D-3L),对CKD患者进行问卷调查,同时收集被调查者一般信息及临床实验室检验结果,并采用相关性检验分析影响CKD患者健康相关的生活质量的因素。结果 EQ-5D-3L中可视化评分(visual analogue scale,VAS)得分情况与健康描述系统评估结果一致,且VAS得分与年龄、血肌酐(Scr)、尿素氮(BUN)、胱抑素C(CysC)、血磷(P)、钙磷乘积(Ca·P)、铁蛋白、尿蛋白/尿肌酐呈负相关,与估算的肾小球滤过率(eGFR)、血红蛋白(Hb)、白蛋白(Alb)、载脂蛋白A1(ApoA1)呈正相关。结论本中心应用EQ-5D-3L进行的调查提示,CKD患者中女性更容易出现焦虑沮丧状态,肾功能情况、贫血及微炎症状态对患者生活质量的影响较为显著,也进一步验证这一简明易行的量表反映肾脏病患者的健康相关的生活质量的效能。
Objective To evaluate the health-related quality of life in patients with chronic kidney disease （CKD）, and to analyze the factors possibly affecting their health-related quality of life. Methods The Chinese version of the EuroQol Group＇s 5-Domain 3 Level Questionnaire （EQ-5D-3L） was used for the CKD patients. Their general information and laboratory examination results were collected, and correlation analysis was conducted to found out the factors that affect the quality of life in CKD patients. Results The visual analogue scale （VAS） scores were consistent with the evaluation results from health description system. The VAS scores were negatively correlated to age, Scr, BUN, CysC, P, Ca x P product, ferritin and UpAJcr, and were positively correlated to eGFR, Hb, Alb and ApoA1. Conclusion Our results demon- strated that anxiety and depression were frequently found in female CKD patients. Renal function, anemia and micro-inflammation state significantly affected quality of life. This simple and easy scale can effectively measure the health-related quality of life in CKD patients.
出处
《中国血液净化》
2013年第2期70-73,共4页
Chinese Journal of Blood Purification
