甲硝唑对消化性溃疡的疗效及机理初探

Investigation on Effects and Mechanirns of Metronidazole in Peptic Ulcer

对55例合并幽门弯曲菌感染的消化性溃疡病人分别应用甲硝唑(30例)及甲氰咪胍(25例)进行了治疗,其4周愈合率分别为73％及72％,而对幽门弯曲菌的清除率分别为10％及8％,结果提示甲硝唑可促进溃疡的愈合。但并非由于杀灭幽门弯曲菌的作用。我们还观察了预先使用甲硝唑对大鼠酒精性溃疡的预防作用,结果提示甲硝唑具有胃粘膜保护作用。

55 peptic ulcer patients with Campylobacter pyloridis infection were treated with metronidazole and cimetidine respectively. The ulcer healing rats were 73% and 72%, while clearance rats of Campylobacter pyloridis were 10% 8% respectively. The results suggest that metronidazole is capable of precipiting the healing of ulcer by a mechanism other than the eradication of Campylobacter pyloridis. Using an ex-vivo gastric chamber technique, we observed that metronidazole was effective in preventing alcoholic ulcer in rats,suggesting that metronidazole has some effect of gastric mucous protection.