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阿莫西林与阿莫西林双氯西林钠对幽门螺杆菌根治的对照研究 被引量:4

The comparative study of amoxicillin and amoxicillin dicloxacillin sodium for the eradication of H.pylori
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摘要 目的评价阿莫西林与阿莫西林双氯西林钠对幽门螺杆菌(H.pylori)的疗效。方法 155例确诊为消化性溃疡(PU)(A期)且H.pylori阳性的患者随机分为3组,A组52例,给予兰索拉唑30 mg+阿莫西林1.0 g+替硝唑0.5 g;B组51例,给予兰索拉唑30 mg+阿莫西林双氯西林钠0.75 g+替硝唑0.5 g;C组52例,给予兰索拉唑30 mg+阿莫西林双氯西林钠1.5 g+替硝唑0.5 g;均每日2次,疗程7 d。停用抗生素至少4周、停用PPI至少2周,复查13C-呼气试验和胃镜尿素酶检查、观察3组H.pylori根除率和溃疡愈合情况,记录药物不良反应(ADR)。结果 3组H.pylori根除率差异有统计学意义(P<0.05),A组与B组间差异有统计学意义(P<0.0167),A组根除率较高;C组与A、B组间差异无统计学意义(P>0.0167)。3组溃疡愈合率差异均无统计学意义(P>0.05)。3组溃疡有效率差异有统计学意义(P<0.05),A组与B组差异有统计学意义(P<0.0167),A组较高;C组与A、B组间差异无统计学意义。3组ADR差异无统计学意义(P>0.05)。结论阿莫西林对H.Pylori根除率高,溃疡有效率较高,ADR发生率低。 Objective To evaluate effecacy of amoxicillin and amoxicil- lin dicloxacillin sodium for the eradication of H. pylori. Methods Total- ly 155 helicobaeter pylori -infected patients with peptic ulcer diagnosed by endoscopy were enrolled. The patients were randomly divided into three groups, and drugs were given as follows: each of the 52 patients of group A was given lansoprazole 30 mg + amoxicillm 1.0 g + tinidazole 0.5 g ; each of the 51 patients of group B was given lansoprazole 30 mg+ amoxicillin dicloxaeillin sodium 0.75 g + tinidazole 0.5 g ; each of the 52 patients of group C was given lansoprazole 30 mg+ amoxicillin dicloxacillin sodium 1.5 g + tinidazole 0. 5 g. All drugs were given twice a day for seven days. After finishing of H. pylori therapy at least four weeks, and after withdrawing of PPI at least two weeks, we compared tile H. pylori status, ulcer healing, and side -effects among three groups by inquisition, endosecopy and 13C breathing test. Results There was sig- nificant difference of the H. pylori eradication rate among the three groups (P 〈 0.05 ). The results between group A and group B were significantly different(P 〈0. 0167). The results between group A and group C was no significant difference, either was the results between group B and group C. The healing rates of peptic ulcer were no significant difference (P 〉 0. 05 ) among the three groups. There was signifi- cant difference among the three groups ( P 〈 0. 05 ). The results between group A and group B were significantly different (P 〈 0. 0167 ). The results between group A and group C were not significantly different, either were the results between group B and group C. The rate of ADR showed no significant difference among the three groups. Conclusion Comparison of three groups, amoxicillin, which has highest H. pylori eradication rate, highest ulcerative healing, lowest incidence of ADR, is better than amoxicillin dicloxacillin sodium as an antibiotics for H. pylori eradication.
出处 《中国临床药理学杂志》 CAS CSCD 北大核心 2013年第2期106-108,共3页 The Chinese Journal of Clinical Pharmacology
关键词 幽门螺杆菌 阿莫西林 阿莫西林双氯西林钠 H. pylori amoxicillin amoxicillin dicloxacillin sodium comparative study
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