神衰宁丸联合西酞普兰治疗抑郁症随机平行对照研究

Study of Citalopram combined with Shenshuaining Pill in the Treatment of DepressionA Randomized Parallel Controlled Study

[目的]观察神衰宁丸联合西酞普兰治疗抑郁症疗效。[方法]使用随机平行对照方法,对照组32例西酞普兰20mg/d,根据病情需要可以加到40mg/d,1次/d。治疗组32例神衰宁丸(石菖蒲、首乌藤、柏子仁、酸枣仁、合欢皮、五味子、珍珠母、琥珀、朱砂、生地黄、墨旱莲、益智仁,开封市第五人民医院院内协定方),5g/次,2次/d;西药治疗同对照组。连续治疗6周为1疗程。观测临床症状、常规及生化指标、心电图、脑电图、B超等检查,汉密顿抑郁量表(HAMD),不良反应量表(TESS)。连续治疗1疗程,判定疗效。[结果]临床疗效治疗组痊愈17例,显效8例,有效4例,无效3例,总有效率90.63%;对照组痊愈16例,显效6例,有效5例,无效5例,总有效率84.38%;两组无显著差异(P>0.05)。HAMD、SDS评分改善治疗组优于对照组(P<0.05,P<0.01),不良反应发生率治疗组低于对照组(P<0.05)。[结论]神衰宁丸抗抑郁效果良好,与西酞普兰联合应用,明显优于单用西药,克服西药起效慢、副反应多的缺点,提高了患者的依从性,值得推广。

[ Objective ] To study the therapeutic effect of citalopram combined with Shenshuaining in the treatment of depression. [Method]64 patients with depression were divided into the treating group with citalopram （n = 32）, the other 32 patients with the same symptoms as the control group with citalopram combined with shenshuaining. After the continuous treatment for 6 weeks, to evaluate the efficacy with HAMD and TESS. There was no significant difference in the efficacy between the two groups （P 〉 0.05 ） , but therapeutic effect of the treatment group is better than the control group（ P 〈 0.05, P 〈 0.01 ） , the probability of adverse reaction of the treatment group is lower than the control group （ P 〈 0.05 ）. [ Conclusion ] Citalopram combined with shenshuaining had superior therapeutic effect for , and is a kind of rapid and safe drug in the treatment of de- pression.